Lithospermate B

CAS No. 122021-74-3

Lithospermate B ( Monomethyl lithospermate B )

Catalog No. M22076 CAS No. 122021-74-3

Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 222 In Stock
10MG 331 In Stock
25MG 536 In Stock
50MG 777 In Stock
100MG 1044 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Lithospermate B
  • Note
    Research use only, not for human use.
  • Brief Description
    Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.
  • Description
    Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.improves renal failure.magnesium lithospermate B (MLB) dose-dependently inhibited the activation of microglia and reduced neuronal apoptosis.?Western blot analysis showed that MLB decreased the expression of inflammatory cytokine TNF- and pro-apoptotic protein cleaved caspase-3.?More importantly, MLB increased the expression of SIRT1, while inhibited the acetylation of NF-B.?Furthermore, pretreatment with sirtinol (a selective inhibitor of SIRT1) reversed all the aforementioned effects of MLB after SAH.?magnesium lithospermate B (MLB), a bioactive ingredient extracted from Salvia miltiorrhiza, exerts neuroprotective effects in several central nervous system insults.administration of MLB significantly attenuated brain edema and neurological deficits after SAH.
  • Synonyms
    Monomethyl lithospermate B
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    122021-74-3
  • Formula Weight
    740.9
  • Molecular Formula
    C36H28MgO16
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [Mg++].Oc1ccc(\C=C\C(=O)OC(Cc2ccc(O)c(O)c2)C([O-])=O)c2C(C(Oc12)c1ccc(O)c(O)c1)C(=O)OC(Cc1ccc(O)c(O)c1)C([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yucong P , Pingyou H , Linfeng F , et al. Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats[J]. The American Journal of Chinese Medicine, 2018, 46:1-17.
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